Organic letters

Flexible Routes to Thiophenes

H Jullien, B Quiclet-Sire, T Tétart, SZ Zard

文献索引：Jullien, Helene; Quiclet-Sire, Beatrice; Tetart, Thomas; Zard, Samir Z. Organic Letters, 2014 , vol. 16, # 1 p. 302 - 305

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被引用次数: 14

摘要

Not surprisingly, therefore, numerous methods have been described for their synthesis.(5, 6) The classical Paal–Knorr reaction is still the most frequently used.(7) Substituted thiophenes can also be obtained from a naked thiophene ring by functionalization through α-metalation or β-halogenation.(5) In view of the special importance of thiophenes, new routes are nevertheless still needed. We envisaged, therefore, to exploit the broad applicability of the radical ...