Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents

RP Tangallapally, R Yendapally, RE Lee…

文献索引：Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Lenaerts, Anne J. M.; Lee, Richard E. Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8261 - 8269

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被引用次数: 68

摘要

In an ongoing effort to develop new and potent antituberculosis agents, a second-generation series of nitrofuranyl amides was synthesized on the basis of the lead compound 5- nitrofuran-2-carboxylic acid 3, 4-dimethoxybenzylamide. The primary design consideration was to improve the solubility and consequently the bioavailability of the series by the addition of hydrophilic rings to the benzyl and phenyl B ring core. The synthesis of 27 ...