A study of the Claisen—Eschenmoser reaction for hydroxymethylbenzofurans and-indoles

TI Mukhanova, SY Kukushkin, PY Ivanov…

文献索引：Mukhanova; Kukushkin; Ivanov; Alekseeva; Granik Russian Chemical Bulletin, 2007 , vol. 56, # 2 p. 325 - 329

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摘要

Abstract N, N-Dimethylacetamide dimethyl acetal reacted with 5 (7)-substituted 2-(hydroxy- methyl) benzofurans to give N, N-dimethyl-2-(2-methylbenzofuran-3-yl) acetamides. Analogous reactions with 3-(hydroxymethyl) indole and 1-hydroxy-6-methyl-1, 2, 3, 4- tetrahydro-carbazole afforded N, N-dimethyl-3-(3-indolyl) propionamide and N, N-dimethyl-2- (6-methyl-1, 2, 3, 4-tetrahydrocarbazol-1-yl) acetamide, respectively.