Tetrahedron

A convenient access to 1, 3-disubstituted furo [3, 4-b] indoles by acid ion-exchange resin-catalyzed furan formation

J Basset, M Romero, T Serra, MD Pujol

文献索引：Basset, Joan; Romero, Manel; Serra, Thais; Pujol, M. Dolors Tetrahedron, 2012 , vol. 68, # 1 p. 356 - 362

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被引用次数: 4

摘要

Efficient synthesis of furo [3, 4-b] indoles starting from the corresponding indole is reported. The first route involves derivatization, protection, and deprotection steps, which stretch the syntheses. The second method provides a shorter and more efficient strategy to accessing the furoindole. The innovation starts with alkylation at C-2 of the indole presenting at the C-3 position a ketone-acetal, followed by the cycloaromatization catalyzed by polymeric ion- ...