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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Small molecule inhibitors of anthrax lethal factor toxin

JD Williams, AR Khan, SC Cardinale, MM Butler…

文献索引：Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434

全文：HTML全文

被引用次数: 2

摘要

Abstract This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.

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甲基3-(2-羟基苯基)丙酸甲酯结构式

甲基3-(2-羟基苯基)丙酸甲酯

结构式

三氟乙酸(TFA)结构式

三氟乙酸(TFA)

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

对硝基苯胺结构式

对硝基苯胺

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

2-methyl-6-nitro-1H-quinolin-4-one结构式

2-methyl-6-nitr...

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

4-azido-2-methyl-6-nitroquinoline结构式

4-azido-2-methy...

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

4-氯-2-甲基-6-硝基喹啉结构式

4-氯-2-甲基-6-硝基喹啉

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

2-甲基-6-硝基喹啉-4-胺结构式

2-甲基-6-硝基喹啉-4-胺

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

4-[di(N-Boc)amino]-2-methyl-6-nitroquinoline结构式

4-[di(N-Boc)ami...

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

6-amino-4-[di(N-Boc)amino]-2-methylquinoline结构式

6-amino-4-[di(N...

~%

N-(4-amino-2-methyl-quinolin-6-yl)-2-phenyl-acetamide结构式

N-(4-amino-2-me...

methyl 3-(2-ethoxyphenyl)propionate结构式

methyl 3-(2-eth...

~65%

3-(2-乙氧基苯基)丙酸结构式

3-(2-乙氧基苯基)丙酸

2-methyl-6-nitro-1H-quinolin-4-one结构式

2-methyl-6-nitr...

~71%

4-氯-2-甲基-6-硝基喹啉结构式

4-氯-2-甲基-6-硝基喹啉

对硝基苯胺结构式

对硝基苯胺

~%

4-氯-2-甲基-6-硝基喹啉结构式

4-氯-2-甲基-6-硝基喹啉

4-azido-2-methyl-6-nitroquinoline结构式

4-azido-2-methy...

~96%

2-甲基-6-硝基喹啉-4-胺结构式

2-甲基-6-硝基喹啉-4-胺

对硝基苯胺结构式

对硝基苯胺

~%

2-甲基-6-硝基喹啉-4-胺结构式

2-甲基-6-硝基喹啉-4-胺

2-methyl-6-nitro-1H-quinolin-4-one结构式

2-methyl-6-nitr...

~%

2-甲基-6-硝基喹啉-4-胺结构式

2-甲基-6-硝基喹啉-4-胺

4-氯-2-甲基-6-硝基喹啉结构式

4-氯-2-甲基-6-硝基喹啉

~%

2-甲基-6-硝基喹啉-4-胺结构式

2-甲基-6-硝基喹啉-4-胺

未登录结构式

~93%

3-(5-溴-2-甲氧基苯基)丙酸结构式

3-(5-溴-2-甲氧基苯基)丙酸

间溴苯甲醛结构式

间溴苯甲醛

~%

3-(5-溴-2-甲氧基苯基)丙酸结构式

3-(5-溴-2-甲氧基苯基)丙酸

(E)-methyl 3-(5-bromo-2-methoxyphenyl)acrylate结构式

(E)-methyl 3-(5...

~%

3-(5-溴-2-甲氧基苯基)丙酸结构式

3-(5-溴-2-甲氧基苯基)丙酸

Small molecule inhibitors of anthrax lethal factor toxin

[Bioorganic and Medicinal Chemistry, , vol. 22, # 1 p. 419 - 434]