Synthesis and SAR studies of 3-allyl-4-prenyloxyaniline amides as potent 15-lipoxygenase inhibitors

…, M Alimardani, A Assadieskandar, A Sadeghian…

文献索引：Jabbari, Atena; Davoodnejad, Mahdieh; Alimardani, Maliheh; Assadieskandar, Amir; Sadeghian, Ali; Safdari, Hadi; Movaffagh, Jebraeel; Sadeghian, Hamid Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 18 p. 5518 - 5526

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被引用次数: 10

摘要

15-Lipoxygenases are one of the nonheme iron-containing proteins with ability of unsaturated lipid peroxidation in animals and plants. The critical role of the enzymes in formation of inflammations, sensitivities and some of cancers has been demonstrated in mammalians. Importance of the 15-lipoxygenases leads to development of mechanistic studies, products analysis and synthesis of their inhibitors. In this work new series of the 3- ...