Tetrahedron

Copper (II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4-carboxythiazoles and 4-carboxyoxazoles

Y Wang, Z Li, Y Huang, C Tang, X Wu, J Xu, H Yao

文献索引：Wang, Yiyun; Li, Ziyuan; Huang, Yue; Tang, Changhua; Wu, Xiaoming; Xu, Jinyi; Yao, Hequan Tetrahedron, 2011 , vol. 67, # 38 p. 7406 - 7411

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被引用次数: 17

摘要

A mild copper (II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4- carboxythiazoles and 4-carboxyoxazoles has been developed. Various substrates with alkyl or aryl substitutions at 2-position on azoline ring could be smoothly oxidized to the desired products in good to excellent yields. Moreover, the hydrolysis of the ester group could be avoided under this method.