A practical procedure for reduction of primary, secondary and tertiary amides to amines

JT Reeves, Z Tan, MA Marsini, ZS Han…

文献索引：Reeves, Jonathan T.; Tan, Zhulin; Marsini, Maurice A.; Han, Zhengxu S.; Xu, Yibo; Reeves, Diana C.; Lee, Heewon; Lu, Bruce Z.; Senanayake, Chris H. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 47 - 52

全文：HTML全文

被引用次数: 32

摘要

Abstract A mild and general procedure for reduction of primary, secondary, and tertiary amides using catalytic triruthenium dodecacarbonyl and 1, 1, 3, 3-tetramethyldisiloxane as reductant is described. The reaction is tolerant of numerous functional groups, and the amine products can often be isolated by direct crystallization as hydrochloride salts. The catalyst and silane are commercially available, air stable, and inexpensive, making the ...