Process development of the synthesis of 3, 4, 5-trimethoxytoluene

A Sankaranarayanan…

文献索引：Sankaranarayanan, Ananthakrishnan; Chandalia Organic Process Research and Development, 2006 , vol. 10, # 3 p. 487 - 492

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被引用次数: 4

摘要

3, 4, 5-Trimethoxytoluene (TMT) was synthesized, starting from p-cresol, through bromination followed by methylation to give 3, 5-dibromo-4-methoxytoluene (DBMT). The methoxylation of the latter with sodium methoxide in methanol was studied under pressure and by continuous distillation of the solvent, methanol. The O-methylation reaction preceding the methoxylation was advantageous from the point of view of separation, ...