Chemical research in toxicology

Oxidation of 3-butene-1, 2-diol by alcohol dehydrogenase

RA Kemper, AA Elfarra

文献索引：Kemper, Raymond A.; Elfarra, Adnan A. Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1127 - 1134

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被引用次数: 28

摘要

3-Butene-1, 2-diol (BDD) is a metabolite of the carcinogenic petrochemical 1, 3-butadiene. BDD is produced by cytochrome P450-mediated oxidation of 1, 3-butadiene to butadiene monoxide, followed by enzymatic hydrolysis by epoxide hydrolase. The metabolic disposition of BDD is unknown. The current work characterizes BDD oxidation by purified horse liver alcohol dehydrogenase (ADH) and by cytosolic ADH from mouse, rat, and ...