Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Ø Rist, M Grimstrup, JM Receveur, TM Frimurer…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 3 p. 1177 - 1180

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被引用次数: 7

摘要

... Bioorganic & Medicinal Chemistry Letters. ... We expanded the SAR of the original 2-anilinothiazoleacetic acids hits 4a and 4b by making a diverse set of compounds 4c–4w using the same chemical route outlined in Scheme 1 starting with thioureas IV. ...