Tetrahedron

Carbonylation of 2-chloro-4, 6-dimethoxypyrimidine and 2-(chloromethy)-4, 6-dimethoxypyrimidine

Y Bessard, R Crettaz

文献索引：Bessard, Yves; Crettaz, Roger Tetrahedron, 1999 , vol. 55, # 2 p. 405 - 412

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被引用次数: 13

摘要

The preparation of pyrimidine-2-carboxylates and 2-pyrimidineacetates by alkoxycarbonylation of respectively 2-chloropyrimidine and 2-(chloromethyl) pyrimidine with carbon monoxide in the presence of palladium acetate and 1, 1′-bis (diphenylphosphino) ferrocene is described. The new process uses readily available starting materials and affords the corresponding esters in good yields.