Tetrahedron

The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases

S Kovačková, M Dračínský, D Rejman

文献索引：Kovackova, Sona; Dracinsky, Martin; Rejman, Dominik Tetrahedron, 2011 , vol. 67, # 7 p. 1485 - 1500

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被引用次数: 9

摘要

This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4- hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no ...