Tetrahedron letters

Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin

SL Less, S Handa, K Millburn, PF Leadlay, CJ Dutton…

文献索引：Less, Simon L.; Handa, Sandeep; Millburn, Karen; Leadlay, Peter F.; Dutton, Christopher J.; Staunton, James Tetrahedron Letters, 1996 , vol. 37, # 20 p. 3515 - 3518

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被引用次数: 34

摘要

The preparation of three analogues of the putative diketide biosynthetic precursor (2) and eight analogues of the putative triketide biosynthetic precursor (3) of the acyl tetronic acid ionophore tetronasin, as N-acetylcysteamine thioesters (4),(5),(6),(12),(13),(14),(15),(22),(23 ),(24) and (25) is described. Five examples are 19F-labelled; a new, enantiospecific method for the creation of a fluorinated quaternary α-centre is presented.