Synthesis

New convergent synthesis of carbocyclic nucleoside analogues

OR Ludek, C Meier

文献索引：Ludek, Olaf R.; Meier, Chris Synthesis, 2003 , # 13 p. 2101 - 2109

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被引用次数: 37

摘要

Abstract Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSal-pronucleotide and the ...