Stability Studies of N??Acylimidazoles

…, R Strömberg, E Yeheskiely

文献索引：Zaramella, Simone; Stroemberg, Roger; Yeheskiely, Esther European Journal of Organic Chemistry, 2002 , # 15 p. 2633 - 2639

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被引用次数: 8

摘要

Abstract Studies of the stabilities of a series of N-acylimidazoles towards acidic and basic conditions of potential usefulness for the removal of common temporary protection in peptide and oligonucleotide synthesis are presented. N-Acylimidazoles with a variety of substituents in the acyl component were prepared and treated with 3% trifluoroacetic acid (TFA) in chloroform and with 2% 1, 8-diazabicyclo [5.4. 0] undec-7-ene (DBU) in N, N- ...