In a previous the basis for our approach to the synthesis of thyroxine analogs and potential inhibitors of thyroxine was summarized. The syntheses of eight novel analogs, Ia-d, IIa-c, and I11 are now reported; the synthetic scheme for Id was briefly communicated previously. 3 In view of current theories of thyroxine action and results of testing, the choice of compounds was made on the basis of the postulated relation between activity and ...