Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones

…, M Roshaiah, PG Sankar, A Khadeer, MS Kumar…

文献索引：Das, Jagattaran; Rao, C.V. Laxman; Sastry; Roshaiah; Sankar, P. Gowri; Khadeer, Abdul; Kumar, M. Sitaram; Mallik, Arundhuti; Selvakumar; Iqbal, Javed; Trehan, Sanjay Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 2 p. 337 - 343

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被引用次数: 26

摘要

Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with ...