W-shape nucleic acid (WNA) for selective formation of non-natural anti-parallel triplex including a TA interrupting site

…, H Yamauchi, F Nagatsugi, R Takahashi, Y Taniguchi…

文献索引：Sasaki, Shigeki; Yamauchi, Hiroyuki; Nagatsugi, Fumi; Takahashi, Ryo; Taniguchi, Yosuke; Maeda, Minoru Tetrahedron Letters, 2001 , vol. 42, # 39 p. 6915 - 6918

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被引用次数: 29

摘要

Novel nucleoside analogs have been designed for selective formation of anti-parallel triplexes including a TA or a CG interrupting site. The new compounds are constructed of a W-shape bicyclic nucleic acid (WNA) bearing an aromatic ring as a stacking motif and a guanine for the formation of Hoogesteen hydrogen bonds, and are expected to effect triplex stabilization by both stacking and complementary hydrogen bonds. Purine-rich triplex- ...