Ruthenium??Catalyzed Transfer Hydrogenation of Amino??and Amido??Substituted Acetophenones

AJA Watson, AJ Fairbanks

文献索引：Watson, Andrew J. A.; Fairbanks, Antony J. European Journal of Organic Chemistry, 2013 , # 30 p. 6784 - 6788

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被引用次数: 2

摘要

Abstract The ruthenium-catalyzed transfer hydrogenation of electron-rich amino-substituted acetophenones is reported. Variation of the reductant, ligands, base, and solvent allowed reaction optimization. A key discovery was the use of 1, 4-butanediol as an irreversible reducing agent, which significantly improved the conversion. A range of amino-and amido- substituted aryl ketones were explored, and they all gave the corresponding alcohols in ...