A New Method for Constructing Quaternary Carbon Centres: Tandem Rhodium??Catalysed 1, 4??Addition/Intramolecular Cyclisation

J Le Notre, D van Mele, CG Frost

文献索引：Le Notre, Jerome; Van Mele, David; Frost, Christopher G. Advanced Synthesis and Catalysis, 2007 , vol. 349, # 3 p. 432 - 440

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被引用次数: 14

摘要

Abstract The efficient tandem rhodium-catalysed 1, 4-addition/cyclisation of 1, 1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.