Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

…, H Hufnagel, T Markotan, J Lanter, C Cai, C Hou…

文献索引：Zhang, Xuqing; Hufnagel, Heather; Markotan, Thomas; Lanter, James; Cai, Chaozhong; Hou, Cuifen; Singer, Monica; Opas, Evan; McKenney, Sandra; Crysler, Carl; Johnson, Dana; Sui, Zhihua Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5577 - 5582

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被引用次数: 17

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 4-azetidinyl-1-aryl-cyclohexanes as potent CCR2 antagonists with high selectivity over activity for the hERG potassium channel is discovered through divergent SARs of CCR2 and hERG. ... A series of 4-azetidinyl-1-aryl-cyclohexanes as potent CCR2 antagonists with high ...