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An efficient direct α-alkylation of ketones with primary alcohols catalyzed by [Ir (cod) Cl] 2/PPh3/KOH system without solvent

K Taguchi, H Nakagawa, T Hirabayashi…

文献索引:Taguchi, Kazuhiko; Nakagawa, Hideto; Hirabayashi, Tomotaka; Sakaguchi, Satoshi; Ishii, Yasutaka Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 72 - 73

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被引用次数: 166

摘要

α-Alkylation of ketones was successfully achieved by the reaction of ketones with alcohols catalyzed by iridium complexes in the presence of a small amount of base. For example, 2- octanone was allowed to react with butanol under the influence of [Ir (cod) Cl] 2/PPh3/KOH to give 6-dodecanone in good yield. The reaction was found to proceed by using a 1: 1 mixture of ketone and alcohol without use of any solvent.