Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2, 3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl) methyl] …

…, T De Paulis, L Johansson, Y Kumar…

文献索引：Hogberg; De Paulis; Johansson; Kumar; Hall; Ogren Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2305 - 2309

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被引用次数: 34

摘要

R isomer 7, the 3-hydroxy analogue 8, the desbromo derivative 9, the monomethoxy compound 10, and the 2, 4-dimethoxy analogue 11, have been synthesized from the corresponding benzoic acids. The benzamides, lacking o-hydroxy groups, were evaluated for their affinity for the [3H] spiperone binding site and for their inhibition of apomorphine- induced behavioral responses in relation to the effect of the corresponding salicylamides. ...