Synthesis and antiviral activity of halogenated adamantylphenols

…, OA Safonova, IY Korsakova, NS Bogdanova…

文献索引：Shvedov, V. I.; Safonova, O. A.; Korsakova, I. Ya.; Bogdanova, N. S.; Nikolaeva, I. S.; et al. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 127 - 130 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 54 - 57

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被引用次数: 23

摘要

We synthesized 4-(l-adamantyl) phenol (llI)[3] and 4-(l-adamantyl) resorcinol (IV) by refluxing l-bromoadamantane with phenol or resorcinol in benzene until the evolution of hydrogen bromide ceased. We were able to get both the mono and dibromo derivatives by bromination of (III), depending on the reaction conditions. 2, 6-Dibromo-4-(l-adamantyl) phenol (V) was formed in 89.3% yield when III was treated with bromine in a mixture of ...