Discovery of 5-[5-fluoro-2-oxo-1, 2-dihydroindol-(3 Z)-ylidenemethyl]-2, 4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylaminoethyl) amide, a novel tyrosine kinase …

L Sun, C Liang, S Shirazian, Y Zhou…

文献索引：Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1116 - 1119

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被引用次数: 435

摘要

... Journal of Medicinal Chemistry. ... To improve the antitumor properties and optimize the pharmaceutical properties including solubility and protein binding of indolin-2-ones, a number of different basic and weakly basic analogues were designed and synthesized. ...