Tetrahedron: Asymmetry

A simplified synthesis of (R)-(−)-muscone using a ring-opening reaction of (R)-(+)-β-methyl-β-propiolactone

M Morita, N Mase, H Yoda, K Takabe

文献索引：Morita, Motoaki; Mase, Nobuyuki; Yoda, Hidemi; Takabe, Kunihiko Tetrahedron Asymmetry, 2005 , vol. 16, # 19 p. 3176 - 3182

全文：HTML全文

被引用次数: 20

摘要

A chiral macrocyclic precursor can be constructed via a ring-opening reaction of (R)-(+)-β- methyl-β-propiolactone with a functionalized organocuprate with no loss of enantiomeric excess. The carboxylic acid precursor was used as a chiral building block for the synthesis of chiral muscone and musky macrolactones.