Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

J Yao, H Liu, T Zhou, H Chen, Z Miao, C Sheng…

文献索引：Yao, Jianzhong; Liu, Hongming; Zhou, Ting; Chen, Hai; Miao, Zhenyuan; Sheng, Chunquan; Zhang, Wannian European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 196 - 208

全文：HTML全文

被引用次数: 14

摘要

A series of new echinocandin-like cyclolipohexapeptides were designed and total synthesized via solution phase [3+ 3]-segment coupling strategy with an attempt to improve antifungal activity. The designed compounds showed potent antifungal activities with broad spectrum. In particular, 11 compounds (ie 28a–e, 28g, 28i–j, 29a, 29c and 29e) showed better in vitro antifungal activities against Candida albicans or Aspergillus fumigatus than ...