Tetrahedron letters

Polymer-supported Mitsunobu ether formation and its use in combinatorial chemistry

V Krchňák, Z Flegelová, AS Weichsel, M Lebl

文献索引：Krchnak, Viktor; Flegelova, Zuzka; Weichsel, Aleksandra S.; Lebl, Michal Tetrahedron Letters, 1995 , vol. 36, # 35 p. 6193 - 6196

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被引用次数: 104

摘要

Aromatic hydroxy acids have been attached to a polymeric solid support and the phenolic hydroxy groups have been reacted with a variety of primary and secondary alcohols under the conditions of the Mitsunobu reaction (triphenylphosphine and diethyl azodicarboxylate) in tetrahydrofuran. In most cases the reaction provided a nearly quantitative yield of alkyl aryl ethers, as determined after cleaving the product from the resin. To demonstrate that the ...