Synthesis and Antiprotozoal Activity of N-Alkoxy Analogues of the Trypanocidal Lead Compound 4, 4′-Bis (imidazolinylamino) diphenylamine with Improved Human …

L Nieto, A Mascaraque, F Miller, F Glacial…

文献索引：Nieto, Lidia; Mascaraque, Ainhoa; Miller, Florence; Glacial, Fabienne; Rios Martinez, Carlos; Kaiser, Marcel; Brun, Reto; Dardonville, Christophe Journal of Medicinal Chemistry, 2011 , vol. 54, # 2 p. 485 - 494

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被引用次数: 20

摘要

To improve the blood− brain barrier permeability of the trypanocidal lead compound 4, 4′- bis (imidazolinylamino) diphenylamine (1), five N-alkoxy analogues were synthesized from bis (4-isothiocyanatophenyl) amine and N-alkoxy-N-(2-aminoethyl)-2- ...