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Design, synthesis, and urease inhibition studies of a series of 4-amino-5-aryl-3H-1, 2, 4-triazole-3-thiones

S Hameed, KA Yasin, T Akhtar, KM Khan

文献索引:Khan, Mahmood-Ul-Hassan; Hameed, Shahid; Yasin, Khawaja A.; Akhtar, Tashfeen; Khan, Khalid M. Monatshefte fur Chemie, 2010 , vol. 141, # 4 p. 479 - 484

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被引用次数: 22

摘要

Abstract A series of 4-amino-5-aryl-3 H-1, 2, 4-triazole-3-thiones was synthesized by reaction of aryl hydrazides with CS 2 and hydrazine hydrate. The synthesized compounds were characterized by spectroanalytical techniques, and their urease inhibition activity was evaluated using jack bean urease. All but one of the synthesized compounds were active, and two of them were found to be more potent than the standard, with 50% inhibition ...