New hypotheses for the binding mode of 4-and 7-substituted indazoles in the active site of neuronal nitric oxide synthase

E Lohou, J Sopkova-de Oliveira Santos…

文献索引：Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5296 - 5304

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被引用次数: 6

摘要

... Bioorganic & Medicinal Chemistry. ... In this context, considering the laboratory's know-how in indazole chemistry 32 and 33 and the interesting activity of 7-NI (IC 50 = 0.71 μM) 26 which furthermore reveals a good in vivo selectivity towards nNOS, design, synthesis and ...