Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyllotoxin as potent inhibitors of human DNA …

XM Zhou, ZQ Wang, JY Chang, HX Chen…

文献索引：Zhou; Wang; Chang; Chen; Cheng; Lee Journal of Medicinal Chemistry, 1991 , vol. 34, # 12 p. 3346 - 3350

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被引用次数: 71

摘要

A number of new 4'-O-demethylepipodophyllotoxin derivatives possessing various 48-N-or 48-0-benzyl groups have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase I1 as well as for their activity in causing cellular protein- linked DNA breakage. The 48-N-benzyl derivatives 9-22 are, in general, as active or more active than etoposide (I). The most active compounds are 14, 16, and 17, which are more ...