Tetrahedron letters

Preparation of unsymmetrical biaryls via Ni-or Pd-catalyzed coupling of aryl chlorides with arylzincs

JA Miller, RP Farrell

文献索引：Miller, Joseph A.; Farrell, Robert P. Tetrahedron Letters, 1998 , vol. 39, # 36 p. 6441 - 6444

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被引用次数: 88

摘要

Unsymmetrical biaryls may be prepared in an efficient manner using aryl chlorides as substrates in Negishi-type cross-coupling reactions with arylzinc reagents via either Ni-or Pd- catalysis. Since a wide range of functional groups (eg, nitrile, carbonyl, ester) tolerate arylzinc compounds, this methodology allows for the direct synthesis of biaryls from aryl chlorides possessing these moieties.