Difluoromethylation of alkenes via borohydride reduction of 1, 3-dibromo-1, 1-difluoroalkanes

J Gonzalez, CJ Foti, S Elsheimer

文献索引：Gonzales, Javier; Foti, Christopher J.; Elsheimer, Seth Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4322 - 4325

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被引用次数: 34

摘要

The synthesis of difluoromethyl-substituted compounds has been an area of active interest, as many of these compounds have been found to be biologically active.'The difluoromethyl group has been classically prepared by geminal difluorination of a corresponding aldehyde. 2* s More recently the use of fluorinated building blocks in synthesis has gained increasing popularity, and methods involving these are being reported for the synthesis of ...