Tetrahedron letters

Lipase catalyzed synthesis of macrocyclic lactones in organic solvents

A Makita, T Nihira, Y Yamada

文献索引：Makita, Atushi; Nihira, Takuya; Yamada, Yasuhiro Tetrahedron Letters, 1987 , vol. 28, # 7 p. 805 - 808

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被引用次数: 126

摘要

Abstract A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described. The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents. This procedure is also applicable to the synthesis of asymmetric lactones.