Bulletin of the Chemical Society of Japan

Total synthesis of antibiotic althiomycin.

K Inami, T Shiba

文献索引：Inami; Shiba Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 1 p. 352 - 360

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被引用次数: 38

摘要

Total Synthesis of antibiotic althiomycin has been achieved starting from D-cysteine. The imide bond between thiazoline and the pyrrolinone part was constructed by coupling reaction of sodium salt of pyrrolinone with cysteine active ester or by photoreaction with diketene. The hydroxymethyl group attached on the carbon adjacent to C-2 of the thiazoline ring, was introduced by aldol condensation posterior to the thiazoline ring formation. The ...