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Preparation of phospholipid analogues using the phosphoramidite route

…, MJ Driver, JC Russell, PG Sammes

文献索引:Browne, Judith E.; Driver, Michael J.; Russell, Jeremy C.; Sammes, Peter G. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 653 - 657

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被引用次数: 14

摘要

The phosphoramidite route has been used to prepare phospholipid analogues possessing biocompatible properties and the monomer 2-(methacryloyloxy) ethylphosphorylcholine, utilised in the preparation of biocompatible polymers. Modifications to established methodology include, as an alternative to the thermally unstable tetrazole, the use of 4, 5- dichloroimidazole as an acid catalyst for preparing phosphite esters from the ...