Journal of medicinal chemistry

Synthesis and flow cytometric evaluation of novel 1, 2, 3, 4-tetrahydroisoquinoline conformationally constrained analogues of nitrobenzylmercaptopurine riboside ( …

Z Zhu, J Furr, JK Buolamwini

文献索引：Zhu, Zhengxiang; Furr, John; Buolamwini, John K. Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837

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被引用次数: 25

摘要

Novel regioisomers of conformationally constrained analogues of the potent es nucleoside transporter ligand, nitrobenzylmercaptopurine riboside (NBMPR), designed for probing its bound (bioactive) conformation, were synthesized and evaluated as es transporter ligands by flow cytometry. Purine 6-position 5, 6, 7, or 8-nitro-1, 2, 3, 4-tetrahydroisoquinolylpurine ribosides, in which the nitrobenzyl moiety in NBMPR has been locked into the nitro-1, 2, 3, ...