... 0 1983 American Chemical Society Page 2. 266 J. Am. Chem. ... SOC. 1964, 5-15. (40) (a) For a review of isotope effects in elimination reactions, see: Smith, PJ In 'Isotopes in Organic Chemistry"; Bund, E., Lee, CC, Eds.; Elsevier: Amsterdam, 1976; Vol. ... Chem. SOC., Vol. 105, No. ...