Tetrahedron Letters

Efficient copper-catalyzed intramolecular N-arylation for the synthesis of oxindoles

YH Jhan, TW Kang, JC Hsieh

文献索引：Jhan, Yu-Huei; Kang, Ting-Wei; Hsieh, Jen-Chieh Tetrahedron Letters, 2013 , vol. 54, # 9 p. 1155 - 1159

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被引用次数: 12

摘要

An efficient copper-catalyzed intramolecular N-arylation was performed by using substituted 2-(2-bromoaryl) acetamide with a small amount of Cu2O and benzene-1, 2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields of oxindoles with tolerance of a wide variety of substrates.