前往化源商城

Strategies for the selective functionalization of dichloropyridines at various sites

E Marzi, A Bigi, M Schlosser

文献索引:Marzi, Elena; Bigi, Anna; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376

全文:HTML全文

被引用次数: 32

摘要

Abstract Whereas 2, 3-dichloropyridine and 2, 5-dichloro-4-(lithiooxy) pyridine undergo deprotonation exclusively at the 4-and 2-positions, respectively, optional site selectivity can be implemented with 2, 5-and 3, 4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4-or 6-and either the 2-and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2, 4-dichloro-3-iodopyridine, 3, 5-dichloro-4 ...

 相关合成线路

~74%

~78%

~65%

~25%

~%

~%

~%

~57%

~97%

~%

~%

~%

~80%

~89%

~87%

~88%

~66%

~64%

~%

~%

~74%