Metabolism of genistein by rat and human cytochrome P450s
ES Roberts-Kirchhoff, JR Crowley…
文献索引：Roberts-Kirchhoff, Elizabeth S.; Crowley, Jan R.; Hollenberg, Paul F.; Kim, Hyesook Chemical Research in Toxicology, 1999 , vol. 12, # 7 p. 610 - 616
The metabolism of genistein (4', 5, 7-trihydroxyisoflavone), a phytoestrogen derived from soy products, was investigated using rat and human liver microsomes and recombinant human cytochrome P450 enzymes. Metabolism of genistein by microsomes obtained from rats treated with pyridine, phenobarbital, β-naphthoflavone, isosafrole, pregnenolone-16α- carbonitrile, or 3-methylcholanthrene resulted in very different product profiles consisting ...
