N 1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors

AI Hernández, O Familiar, A Negri…

文献索引：Coyle, Susan; Hallett, Allan; Munns, Michael S.; Young, Geoffrey T. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 522 - 528

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被引用次数: 19

摘要

... Journal of Medicinal ... 26b) that also inhibit HSV-1 TK were able to reverse the cytostatic activity of 1-(β-d-arabinofuranosyl)thymine (Ara-T) and ganciclovir ... the following features: 11 (i) the nucleic base is crucial for the interaction of these inhibitors with the target enzyme(s) (eg, it ...