Indoloquinolizidine–Peptide Hybrids as Multiple Agonists for D1 and D2 Dopamine Receptors

…, C Lluís, R Franco, F Albericio, M Royo

文献索引：Vendrell, Marc; Angulo, Ester; Casado, Vicent; Lluis, Carme; Franco, Rafael; Albericio, Fernando; Royo, Miriam Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3062 - 3069

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被引用次数: 10

摘要

Abstract Multiple-specificity ligands are considered promising pharmacological tools that may show higher efficacy in the treatment of diseases for which the modulation of a single target is therapeutically inadequate. We prepared a set of novel ligands for D 1 and D 2 dopamine receptors by combining two indolo [2, 3-a] quinolizidine scaffolds with various tripeptide moieties. The binding and functional properties of these molecules were ...