Tetrahedron letters

Practical and efficient synthesis of N-fused tricyclic indoles

N Koay, DL Tonelli, VL Truong

文献索引：Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh Tetrahedron Letters, 2011 , vol. 52, # 1 p. 122 - 124

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被引用次数: 3

摘要

A practical and efficient synthesis of methyl 6, 7, 8, 9-tetrahydropyrido [1, 2-a] indol-10- ylacetate derivatives 6 is reported. This synthetic approach featured the nucleophilic aromatic substitution of 2-piperidinemethanol derivatives 2 with aryl fluorides 1, and the intramolecular Heck coupling as key steps to afford the desired N-fused tricyclic indoles 6.