Chemical Development of the Casein Kinase I-Epsilon Inhibitor: 3-(3-Fluorophenyl) sulfanyl-1 H-pyrrolo [3, 2-b] pyridine-2-carboxylic Acid Amide

BG Huang, G Kubiak, JJ Shay…

文献索引：Organic Process Research and Development, , vol. 15, # 5 p. 1040 - 1045

被引用次数: 2

摘要

... Organic Process Research & Development. ... was reported to provide 2-methyl-3-nitropyridine in 63% yield after vacuum distillation.(9) The procedure used to ... A process with a better safety profile was developed using diethyl malonate and a base (Scheme 2). After a base ...

18699-87-1

2-甲基-3-硝基吡啶

17288-35-6

1H-吡咯并[3,2-B]吡啶-2-羧酸

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Detailed structure–activity relationship of indolecarboxamid...

[Engelhardt, Harald; De Esch, Iwan J.P.; Kuhn, Daniel; Smits, Rogier A.; Zuiderveld, Obbe P.; Dobler, Julia; Mayer, Moriz; Lips, Sebastian; Arnhof, Heribert; Scharn, Dirk; Haaksma, Eric E.J.; Leurs, Rob European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 660 - 668]

Chemical Development of the Casein Kinase I-Epsilon Inhibito...

[Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045]

Detailed structure–activity relationship of indolecarboxamid...

[European Journal of Medicinal Chemistry, , vol. 54, p. 660 - 668]