Tetrahedron letters

Lateral lithiation of ethyl 4-acetyl-5-methyl-3-isoxazolyl carboxylate with 5, 5-dimethyl-1, 3-dioxanyl as a directing group

P Zhou, NR Natale

文献索引：Zhou, Peiwen; Natale Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8249 - 8252

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被引用次数: 12

摘要

Lateral lithiation of ethyl 4-acetyl-5-methyl-3-isoxazolyl carboxylate, a functionalized isoxazole AMPA analog, occurs cleanly at the C-5 methyl group with 5, 5-dimethyl-1, 3- dioxanyl as a directing group. The 4-acetyl isoxazole derivatives were transformed