Tetrahedron Letters

Rapid reduction of heteroaromatic nitro groups using catalytic transfer hydrogenation with microwave heating

JF Quinn, CE Bryant, KC Golden, BT Gregg

文献索引：Quinn, John F.; Bryant, Cole E.; Golden, Kathryn C.; Gregg, Brian T. Tetrahedron Letters, 2010 , vol. 51, # 5 p. 786 - 789

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被引用次数: 30

摘要

A method for the rapid, safe reduction of heteroaromatic and aromatic nitro groups to amines is described using catalytic transfer hydrogenation under microwave heating conditions. Commonly available Pd/C or Pt/C catalyst is extremely effective with 1, 4-cyclohexadiene as the hydrogen transfer source. In the case of substrates containing potentially labile aromatic halogens, Pt/C is effective and results in little or no dehalogenation. In general, the ...