Tetrahedron Letters

A straightforward and general access to α-phthalimido-α′-substituted propan-2-ones

V Pace, W Holzer

文献索引：Pace, Vittorio; Holzer, Wolfgang Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5106 - 5109

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被引用次数: 10

摘要

The regioselective ring opening of the commercially available N-(2, 3-epoxypropyl) phthalimide with different nucleophiles, to obtain the corresponding phthalimidopropan-2- ols (including a challenging fluorohydrin) followed by the Dess–Martin periodinane oxidation, constitutes a general and widely applicable protocol for the preparation of differently functionalized α-phthalimido-α′-substituted propan-2-ones. The incorporation ...